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6 a.m. to 6:30 p.m. PT
7 days a week
Available Now Coming May 26, 2008
Prepare for feverish puzzle mayhem with Mario!
The doctor is in! Mario takes a break from his adventuring ways and once again dons his stethoscope for a new generation of germ-battling mayhem. In addition to the classic mode of using vitamins to exterminate viruses, you'll find two battle modes and an online multiplayer mode where you can hone your skills against players from around the world. Dr. Mario Online Rx is a prescription for fun that everyone can enjoy.
As of May 20, 2014, the Nintendo Wi-Fi Connection service for Nintendo DSi and Wii systems has been retired. Online features of this game are no longer available after this date but this game still provides an entertaining experience in offline mode.
To learn more about this service change, please visit To learn more about this service change, please visit support.nintendo.com/servicesupdate.