Following the defeat and subsequent disappearance of the Mad Gear Gang, a small group known only as “Skull Cross” is responsible for a new uprising of vandalism, terrorism and death. The government of Metro City is at a complete loss. Metro City’s mayor, Mike Haggar, and Guy are prepared to take on the new gang, but before they can act, the door bursts open, revealing Lucia, Cody’s old friend. “Metro City is under attack!” she shouts, “Skull Cross is loose, and they’ve got something up their sleeves.” But before any of them can move, a mysterious man appears in the doorway. “My name is Dean,” he says. “I know Skull Cross inside-and-out, and I hate them more than anything. I can help you, and you can help me. We must go!” All four fighters vow to bring Skull Cross down. It will be a tough assignment, and may even be their final fight!